Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance.

doi:10.1016/s0026-895x(25)10091-6

Paper

Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance.

Published Jan 1, 1989 · J. M. Ford, Walter C. Prozialeck, W. Hait

Molecular pharmacology

Q1 SJR score

229

Citations

9

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Highly Cited

Study Snapshot

Phenothiazines with hydrophobic nuclei and tertiary amines are more effective in inhibiting cell growth and reversing multidrug resistance in multidrug-resistant breast cancer cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Structural features determining activity of phenothiazines and related drugs for inhibition of cell growth and reversal of multidrug resistance.

Sign up to use Study Snapshot

References

Citations

Antipsychotic Drug Fluphenazine against Human Cancer Cells

Fluphenazine shows potential in reducing the viability of various cancer cells by regulating cell cycle, reducing proliferation, and causing apoptosis.

Treatment of cancer with antipsychotic medications: Pushing the boundaries of schizophrenia and cancer

Antipsychotic medications, such as methylene blue and reserpine, show potential in treating various cancers and may have molecular similarities with schizophrenia.

A Double-Edged Sword: Thioxanthenes Act on Both the Mind and the Microbiome

Thioxanthenes show potential as both neuroleptics and antimicrobial agents, offering potential for novel antibacterial agents in the face of antibiotic resistance.

Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents.

Small molecule modulators of protein Ser/Thr phosphatase 2A (PP2A) show potential for reducing cell proliferation and survival in cancer therapy, with potential for near-term translation to the clinic for cancer and other human diseases.

Kinetics of human butyrylcholinesterase inhibition by 1,9-dimethyl-methylene blue

DMMB, a potent cholinesterase inhibitor, may help design new treatments for Alzheimer's disease by effectively inhibiting human butyrylcholinesterase at nM levels.

Synthesis and characterization of a new class of phenothiazine molecules with 10H-substituted morpholine & piperidine derivatives: A structural insight

A new class of 10H-substituted phenothiazine molecules was synthesized and characterized, revealing their crystal packing is influenced by O–H⋯O, C–H⋯O, and π–π interactions.

In vitro anticancer activity of fluphenazine, perphenazine and prochlorperazine. A review

Fluphenazine, perphenazine, and prochlorperazine show potential in treating various human cancers by inhibiting cancer cell viability and promoting apoptosis.

Repurposing old drugs to fight multidrug resistant cancers.

Drug repurposing using in silico approaches can effectively combat multidrug resistant cancers, offering potential for new cancer treatments.

Influence of phenothiazine molecules on the interactions between positively charged poly-l-lysine and negatively charged DPPC/DPPG membranes.

Phenothiazines modify the secondary structure of positively charged poly-l-lysine molecules and alter their effect on negatively charged DPPC/DPPG membranes, potentially impacting their biological actions.