Walsuronoid A (1), a limonoid featuring an unprecedented 3,4-peroxide-bridged A-seco skeleton, together with walsuronoids B (2) and C (3) possessing a rare 18(13-->14)-abeo-limonoid skeleton, was isolated from Walsura robusta. The structures were elucidated by spectroscopic analysis and chemical correlation, and that of 1 was confirmed by single-crystal X-ray diffraction. Biosynthetic pathway of 2 and 3 was proposed and was chemically mimicked. Compounds 1 and 2 showed weak antimalarial activity.

Walsuronoids A and B show weak antimalarial activity, while walsuronoids C and D show potential as a new class of antimalarial compounds.

Paper

The first limonoid peroxide in the Meliaceae family: walsuronoid A from Walsura robusta.

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