The first asymmetric synthesis of (2S,3S,4R)-3-amino-2-hydroxymethyl-4-hydroxypyrrolidine

doi:10.1016/J.TETLET.2005.06.025

Paper

The first asymmetric synthesis of (2S,3S,4R)-3-amino-2-hydroxymethyl-4-hydroxypyrrolidine

Published Aug 8, 2005 · K. Curtis, J. Fawcett, S. Handa

Tetrahedron Letters

Q3 SJR score

17

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Abstract

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Study Snapshot

The novel (2S,3S,4R)-3-amino-2-hydroxymethyl-4-hydroxypyrrolidine (5-hydroxypyrrolidine) can be efficiently synthesized from trans-4-hydroxy-l-proline (8-hydroxypyrrolidine) using a tethered aminohydroxylation step.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

The first asymmetric synthesis of (2S,3S,4R)-3-amino-2-hydroxymethyl-4-hydroxypyrrolidine

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