Paper
Five-membered 2,3-dioxo heterocycles: LIV. Double spiro heterocyclization of methyl 1-aryl-3-benzoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates with 3-arylamino-5,5-dimethylcyclohex-2-en-1-ones
Published Sep 1, 2007 · Yu. N. Bannikova, A. N. Maslivets, Z. G. Aliev
Russian Journal of Organic Chemistry
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Abstract
Methyl 1-aryl-3-benzoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates reacted with 3-arylamino-5,5-dimethylcyclohex-2-en-1-ones in boiling benzene to give the corresponding 1,1′-diaryl-3′-benzoyl-4′-hydroxy-6,6-dimethyl-1,1′,2,4,5,5′,6,7-octahydrospiro[indole-3,2′-pyrrole]-2,4,5′-triones and 1′-aryl-4-arylamino-3-benzoyl-6′,6′-dimethyl-1′,2′,4′,5′,6′,7′-hexahydro-5H-spiro[furan-2,3′-indole]-2′,4′,5-triones whose structure was proved by X-ray analysis.
This study demonstrates the double spiro heterocyclization of methyl 1-aryl-3-benzoyl-4,5-dioxo-4,5-dihydro-1H-pyrrole-2-carboxylates with 3-arylamino-5,5-dimethylcyclohex
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