Paper
Flavonoids: Promising anticancer agents
Published Jul 1, 2003 · DOI · Wenying Ren, Z. Qiao, Hongwei Wang
Medicinal Research Reviews
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Citations
24
Influential Citations
Abstract
Flavonoids are polyphenolic compounds that are ubiquitously in plants. They have been shown to possess a variety of biological activities at nontoxic concentrations in organisms. The role of dietary flavonoids in cancer prevention is widely discussed. Compelling data from laboratory studies, epidemiological investigations, and human clinical trials indicate that flavonoids have important effects on cancer chemoprevention and chemotherapy. Many mechanisms of action have been identified, including carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis and differentiation, inhibition of angiogenesis, antioxidation and reversal of multidrug resistance or a combination of these mechanisms. Based on these results, flavonoids may be promising anticancer agents. © 2003 Wiley Periodicals, Inc. Med Res Rev, 23, No. 4, 519–534, 2003
Flavonoids show promising anticancer effects through various mechanisms, including carcinogen inactivation, antiproliferation, cell cycle arrest, induction of apoptosis, inhibition of angiogenesis, antioxidation, and reversing multidrug resistance.
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