Paper
Decarboxylative Fluorination of Electron-Rich Heteroaromatic Carboxylic Acids with Selectfluor.
Published Mar 3, 2017 · Xi Yuan, Jian-Fei Yao, Zhen-Yu Tang
Organic letters
Q1 SJR score
53
Citations
0
Influential Citations
Abstract
A transition-metal-free decarboxylative fluorination of electron-rich five-membered heteroaromatics, including furan-, pyrazole-, isoxazole-, thiophene-, indole-, benzofuran- and indazolecarboxylic acids, with Selectfluor is reported. Fluorinated dimer products were observed for nitrogen-containing heteroaromatic carboxylic acids, such as indole and pyrazole. An effective method has been developed to synthesize the monomer of 2- and 3-fluoroindoles with Li2CO3 as base at low temperature.
Study Snapshot
Selectfluor effectively decarboxylates electron-rich heteroaromatic carboxylic acids, enabling the synthesis of 2- and 3-fluoroindoles at low temperatures.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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