Fmoc-amino acid chlorides in solid phase synthesis of opioid peptides.

doi:10.1111/j.1399-3011.1992.tb00789.x

Paper

Fmoc-amino acid chlorides in solid phase synthesis of opioid peptides.

Published Jan 12, 2009 · DOI · K. Sivanandaiah, V. Babu, C. Renukeshwar

International journal of peptide and protein research

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Abstract

Fmoc-amino acid chlorides were employed in the solid phase synthesis of the opioid peptides [Leu]enkephalin, [Leu]enkephalin amide, and dermorphin. The conventional polystyrene-based Merrifield resin or Wang's resin served as solid support. A binary salt of either triethylamine or diisopropylethylamine in the presence of 1-hydroxybenzotriazole or pivalic acid was used for acylation. The coupling rates were quite fast, being comparatively faster when 1-hydroxybenzotriazole was used along with triethylamine or diisopropylethylamine. The peptides obtained in good yields showed, after purification, biological and spectral properties identical with those of the natural peptides.

Study Snapshot

Fmoc-amino acid chlorides effectively synthesized opioid peptides with biological and spectral properties identical to their natural counterparts, providing a promising method for pharmaceutical development.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Fmoc-amino acid chlorides in solid phase synthesis of opioid peptides.

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