Paper
Formation of pyroglutamylglutamine (or asparagine) diketopiperazine in 'non-classical' conditions: a side reaction in peptide synthesis.
Published Jan 12, 2009 · A. Mazurov, S. Andronati, T. I. Korotenko
International journal of peptide and protein research
UNKNOWN SJR score
11
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0
Influential Citations
Abstract
Formation of by-products pyroglutamylglutamine diketopiperazine (5a) or pyroglutamylasparagine diketopiperazine (5b) were observed during the condensation of pyroglutamic acid active ester with C-protected glutaminyl(or asparaginyl)-proline derivatives. Successful synthesis of Glp-Gln(or Asn)-Pro-derivatives is possible after coupling of Glp-Gln(or Asn)-OH with proline-derivatives.
Study Snapshot
Pyroglutamylglutamine diketopiperazine formation is a side reaction in peptide synthesis, allowing for the successful synthesis of Glp-Gln(or Asn)-Pro-derivatives.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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