Paper
An essential cytoplasmic function for the nuclear poly(A) binding protein, PABP2, in poly(A) tail length control and early development in Drosophila.
Published Oct 1, 2005 · B. Benoit, Géraldine Mitou, A. Chartier
Developmental cell
Q1 SJR score
105
Citations
8
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro Study
Highly CitedStudy Snapshot
PABP2 plays a crucial role in early development by regulating maternal mRNA poly(A) tail length, crucial for Cyclin B protein levels and embryonic development in Drosophila.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
twin, a CCR4 homolog, regulates cyclin poly(A) tail length to permit Drosophila oogenesis
Twin, a CCR4 homolog, regulates cyclin poly(A) tail length to control Drosophila oogenesis by coordinating cyst division, oocyte fate specification, and egg chamber maturation.
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A complex containing the CCR4 and CAF1 proteins is involved in mRNA deadenylation in Drosophila
The CCR4-NOT complex, containing CCR4 and CAF1, plays a role in general and regulated mRNA deadenylation in Drosophila melanogaster.
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Structure and function of poly(A) binding proteins.
Poly(A) binding proteins, PABPC and PABPN1, play crucial roles in initiation of translation and mRNA decay, with their structure and function influencing mRNA processing and mRNA stability.
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Xenopus embryonic poly(A) binding protein 2 (ePABP2) defines a new family of cytoplasmic poly(A) binding proteins expressed during the early stages of vertebrate development
Xenopus ePABP2 is a new family of cytoplasmic poly(A) binding proteins that is expressed during early vertebrate development and may play a role in regulating mRNA function in early vertebrate development.
2004·39citations·P. Good et al.·genesis
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Stimulation of poly(A) polymerase through a direct interaction with the nuclear poly(A) binding protein allosterically regulated by RNA
The nuclear poly(A) binding protein PABPN1 stimulates poly(A) polymerase during mRNA polyadenylation by binding to the substrate RNA, increasing its affinity for RNA without significantly affecting catalytic efficiency.
2003·160citations·Yvonne Kerwitz et al.·The EMBO Journal
The EMBO Journal
Citations
Spatiotemporal regulation of maternal mRNAs during vertebrate oocyte meiotic maturation
The storage, translation, and processing of maternal mRNAs during oocyte maturation are regulated by factors such as mRNA elements and posttranscriptional modifications, contributing to oocyte meiotic progression.
2023·11citations·Yanwen Jiang et al.·Biological Reviews
Biological Reviews
Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy
Increased ubiquitin-proteasome system activity contributes to muscle atrophy in oculopharyngeal muscular dystrophy, suggesting that inhibitors of proteasome activity may be a promising pharmacological approach for the disease.
2022·19citations·Cécile Ribot et al.·PLoS Genetics
PLoS Genetics
Nuclear poly(A) binding protein 1 (PABPN1) mediates zygotic genome activation-dependent maternal mRNA clearance during mouse early embryonic development
PABPN1 plays a crucial role in maternal mRNA clearance during early embryonic development, potentially contributing to human fertility.
2021·16citations·Long-Wen Zhao et al.·Nucleic Acids Research
Nucleic Acids Research
Revisiting poly(A)‐binding proteins: Multifaceted regulators during gametogenesis and early embryogenesis
PABPs play diverse roles in mRNA metabolism during gametogenesis and early embryogenesis, potentially impacting human fertility through their interaction with multifunctional partners.
2021·14citations·Long-Wen Zhao et al.·BioEssays
BioEssays
The Disease-Associated Proteins Drosophila Nab2 and Ataxin-2 Interact with Shared RNAs and Coregulate Neuronal Morphology
Drosophila Nab2 and Atx2 interact with shared RNAs and coordinately regulate neuronal morphology and adult viability, offering insights into their neuronal functions and interactions.
2021·9citations·J. Rounds et al.·bioRxiv
bioRxiv
Targeting pathological tau by small molecule inhibition of the poly(A):MSUT2 RNA-protein interaction.
Inhibiting the poly(A):MSUT2 RNA-protein interaction could reduce pathological tau accumulation in Alzheimer's disease and related dementia disorders.
2020·18citations·Jeremy D. Baker et al.·ACS chemical neuroscience
ACS chemical neuroscience
A Genetic Screen Links the Disease-Associated Nab2 RNA-Binding Protein to the Planar Cell Polarity Pathway in Drosophila melanogaster
Nab2 RNA-binding protein is linked to the planar cell polarity pathway in developing eyes, wings, and germline in Drosophila.
2019·6citations·K. Moberg et al.·G3: Genes|Genomes|Genetics
G3: Genes|Genomes|Genetics
A Promising Future for Stem-Cell-Based Therapies in Muscular Dystrophies—In Vitro and In Vivo Treatments to Boost Cellular Engraftment
Combining genetic, biochemical, and cell culture treatments may lead to safer and more efficient stem-cell-based therapies for muscular dystrophy patients.
2019·7citations·Daniela Gois Beghini et al.·International Journal of Molecular Sciences
International Journal of Molecular Sciences
Inhibition of myostatin improves muscle atrophy in oculopharyngeal muscular dystrophy (OPMD)
Inhibiting myostatin may improve muscle atrophy and reduce symptoms in oculopharyngeal muscular dystrophy.
2019·31citations·P. Harish et al.·Journal of Cachexia, Sarcopenia and Muscle
Journal of Cachexia, Sarcopenia and Muscle