Functionalized 6-(piperidin-1-yl)-8,9-diphenyl purines as inverse agonists of the CB1 receptor - SAR efforts towards selectivity and peripheralization.

doi:10.1016/j.bmc.2019.07.002

Paper

Functionalized 6-(piperidin-1-yl)-8,9-diphenyl purines as inverse agonists of the CB1 receptor - SAR efforts towards selectivity and peripheralization.

Published Aug 1, 2019 · G. Amato, R. Wiethe, Amruta Manke

Bioorganic & medicinal chemistry

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4

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Abstract

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Study Snapshot

This study developed novel CB1 inverse agonists with exceptional selectivity for hCB1 and improved physical properties to limit brain exposure, potentially benefiting diabetes, hepatic disorders, and fibrosis treatment.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Functionalized 6-(piperidin-1-yl)-8,9-diphenyl purines as inverse agonists of the CB1 receptor - SAR efforts towards selectivity and peripheralization.

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