Paper
General synthesis of mono-, di-, and tri-acetylated indoles from indolin-2-ones
Published Feb 4, 2011 · Mukund Jha, T. Chou, B. Blunt
Tetrahedron
Q3 SJR score
17
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
This study developed a two-step reaction sequence to produce di- and mono-acetylated indoles from indolin-2-ones, enabling the synthesis of various acetylated indoles.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Promiscuous Candida antarctica lipase B-catalyzed synthesis of β-amino esters via aza-Michael addition of amines to acrylates
This study developed an efficient protocol for regioselective aza-Michael addition of amines to acrylates using CaL B, yielding good yields of -amino esters from various primary and secondary amines and acrylates.
2010·49citations·K. P. Dhake et al.·Tetrahedron Letters
Tetrahedron Letters
Marine indole alkaloids: potential new drug leads for the control of depression and anxiety.
Marine indole alkaloids show potential as new drug leads for treating depression and anxiety, with potential affinity to various neurological targets and impact on animal behavior.
2010·1431citations·Anna J Kochanowska-Karamyan et al.·Chemical reviews
Chemical reviews
Anticancer properties of indole compounds: mechanism of apoptosis induction and role in chemotherapy.
Indole compounds from cruciferous vegetables show anti-cancer properties and chemosensitivity, reducing toxicity and resistance to conventional chemotherapeutic drugs.
2010·129citations·Aamir Ahmad et al.·Current drug targets
Current drug targets
Biological importance of the indole nucleus in recent years: A comprehensive review
Indole nucleus has a wide spectrum of biological activities, including pharmacophore in medicinal compounds and a key component in strychnine and LSD.
2010·461citations·Vikas Sharma et al.·Journal of Heterocyclic Chemistry
Journal of Heterocyclic Chemistry
New and bioactive natural products isolated from madagascar plants and marine organisms.
Madagascar's biodiversity has led to the isolation of 270 new and bioactive natural products, including potential anti-cancer agents.
2010·10citations·Y. Hou et al.·Current medicinal chemistry
Current medicinal chemistry
Enzyme-assisted kinetic resolution of novel 2-naphthol Mannich bases
This study successfully synthesized and resolved novel 2-naphthol Mannich bases, enabling the development of novel Selective Estrogen Receptor Modulators with chirality centers.
2010·8citations·Chandrani Mukherjee et al.·Journal of Molecular Catalysis B-enzymatic
Journal of Molecular Catalysis B-enzymatic
A one-pot, four-component synthesis of a-carboline derivatives
This one-pot method efficiently synthesizes novel 1H-indolo[2,3-b]pyrazolo[4,3-e]pyridines by combining indolin-2-one, 3-oxo-3-phenylpropanenitrile, various hydrazines,
2009·39citations·R. Ghahremanzadeh et al.·Tetrahedron Letters
Tetrahedron Letters
Chemoselective S-benzylation of indoline-2-thiones using benzyl alcohols
Indoline-2-thiones can be selectively S-benzylated using benzyl alcohols, with aryl substituents affecting the reactivity of these alcohols.
2009·17citations·Mukund Jha et al.·Tetrahedron Letters
Tetrahedron Letters
Citations
Unprecedented Multicomponent Reaction of Indoles, CS2 and Nitroarenes: Stereoselective Synthesis of (Z)-3-((arylamino)methylene)indoline-2-thiones.
This study developed a novel multicomponent reaction for the stereoselective synthesis of (Z)-3-((arylamino)methylene)indoline-2-thiones, enabling the easy derivatization to biologically active thieno[2,3-b]indo
2021·1citation·Q. Qin et al.·Chemistry, an Asian journal
Chemistry, an Asian journal
Synthesis of New 4-Oxo-Tetrahydroindol Derivatives by Using Chemical and Microbial Biotransformation Methods
This study successfully synthesized new 4-oxo-tetrahydroindole derivatives using chemical and microbial biotransformation methods, resulting in pharmacologically interesting compounds.
2020·4citations·Z. Caliskan et al.·Polycyclic Aromatic Compounds
Polycyclic Aromatic Compounds
Au-Catalyzed Synthesis of Thiopyrano[2,3-b]indoles Featuring Tandem Rearrangement and Hydroarylation.
Gold(III)-catalyzed synthesis of 14- electron heteroaromatic thiopyrano[2,3-b]indoles using conjugated enyne tethered indole sulfides enables skeletal rearrangement, intramole
2017·22citations·Mukund Jha et al.·Organic letters
Organic letters
New (E)-1-alkyl-1H-benzo[d]imidazol-2-yl)methylene)indolin-2-ones: Synthesis, in vitro cytotoxicity evaluation and apoptosis inducing studies.
Compound 8l shows significant cytotoxic activity against breast cancer cells and induces apoptosis through caspase-3 activation and cleaved PARP expression.
2016·52citations·Pankaj Sharma et al.·European journal of medicinal chemistry
European journal of medicinal chemistry
A convenient synthesis of 3-formyl-2-thioacetamide-indole derivatives via the one-pot reaction of indolin-2-thiones, isocyanides and chloroacetylchloride
This study developed a one-pot method for constructing 3-formyl-2-thioacetamide-indoles by condensing isocyanides with indolin-2-thiones, followed by regioselective reaction with chloroacetylchloride and hydrolysis
2015·9citations·M. Kiamehr et al.·Tetrahedron Letters
Tetrahedron Letters
Access to Substituted Dihydrothiopyrano[2,3-b]indoles via Sequential Rearrangements During S-Alkylation and Au-Catalyzed Hydroarylation on Indoline-2-thiones.
This study developed a general method for synthesis of indole-fused dihydrothiopyrans from indoline-2-thiones, enabling the synthesis of functionalized tricyclic indole derivatives through sequential rearrangements.
2015·25citations·Mukund Jha et al.·The Journal of organic chemistry
The Journal of organic chemistry
BF3 etherate-mediated microwave-assisted facile synthesis of thiopyrano[2,3-b]indol-2-one
This study developed a facile one-step method for synthesis of thiopyrano[2,3-b]indol-2-ones using microwave irradiation, leading to good yields.
2014·13citations·Mukund Jha et al.·Tetrahedron Letters
Tetrahedron Letters
A new route to the versatile synthesis of thiopyrano[2,3-b:6,5-b′]diindoles via 2-(alkylthio)-indole-3-carbaldehydes
This study developed a new method for the versatile synthesis of thiopyrano[2,3-b:6,5-b′]diindoles by condensation of 2-(alkylthio)-indole-3-carbaldehydes with indoline-2-thione
2014·22citations·Mukund Jha et al.·Tetrahedron Letters
Tetrahedron Letters