Paper

Glutathione depletion, lipid peroxidation, DNA double-strand breaks and the cytotoxicity of 2-bromo-3-(N-acetylcystein-S-yl)hydroquinone in rat renal cortical cells.

Published Aug 14, 1992 · S. Vamvakas, D. Bittner, M. Koob

Chemico-biological interactions

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Abstract

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In Vitro Study

Study Snapshot

2-bromo-3-(N-acetylcystein-S-yl)hydroquinone oxidizes renal cells, depleting cellular glutathione, leading to DNA damage and cell death, with antioxidants and calcium chelators effectively protecting cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Glutathione depletion, lipid peroxidation, DNA double-strand breaks and the cytotoxicity of 2-bromo-3-(N-acetylcystein-S-yl)hydroquinone in rat renal cortical cells.

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