Hexadecylphosphocholine disrupts cholesterol homeostasis and induces the accumulation of free cholesterol in HepG2 tumour cells.

doi:10.1016/J.BCP.2005.08.001

Paper

Hexadecylphosphocholine disrupts cholesterol homeostasis and induces the accumulation of free cholesterol in HepG2 tumour cells.

Published Apr 14, 2006 · J. Jiménez-López, M. P. Carrasco, C. Marco

Biochemical pharmacology

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16

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0

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Abstract

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In Vitro Study

Study Snapshot

Hexadecylphosphocholine disrupts cholesterol homeostasis and induces the accumulation of free cholesterol in HepG2 tumor cells, potentially contributing to DNA fragmentation and caspase-3 activation in cancer cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Hexadecylphosphocholine disrupts cholesterol homeostasis and induces the accumulation of free cholesterol in HepG2 tumour cells.

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