Hexahydropyrimidines I. Preparation of 2-substituted-1,3-bis(p-dimethylaminobenzyl)-hexahydropyrimidines

doi:10.1002/JPS.2600511113

Paper

Hexahydropyrimidines I. Preparation of 2-substituted-1,3-bis(p-dimethylaminobenzyl)-hexahydropyrimidines

Published Nov 1, 1962 · J. Billman, L. C. Dorman

Journal of Pharmaceutical Sciences

Q2 SJR score

3

Citations

1

Influential Citations

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Abstract

A number of 2-substituted-1,3-bis(p-dimethylaminobenzyl)hexahydropyrimidines have been prepared by allowing various aldehydes to react with 1, 3-bis(p-dimethyl-amino)propane. The latter diamine was prepared by the catalytic reduction of the di-Schiff base 1, 3-bis(p-dimethylaminobenzylideneamino)propane. It was felt that these compounds might possess antifungal, antibiotic, and antiviral activity.

Study Snapshot

2-substituted-1,3-bis(p-dimethylaminobenzyl)-hexahydropyrimidines show potential antifungal, antibiotic, and antiviral activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Hexahydropyrimidines I. Preparation of 2-substituted-1,3-bis(p-dimethylaminobenzyl)-hexahydropyrimidines

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References

Citations

Cleaner and Efficient Green Chemistry Synthesis of N,N´-Dibenzyl or N,N´-(2-Hydroxybenzyl)-Ethane-1,2-Diamine,-Propane-1,3-Diamine and -1,3-Diamino-2-Propanol

This eco-friendly green chemistry method efficiently synthesizes N,N -dibenzyl or N,N -(2-hydroxybenzyl)diamines using water as a solvent, without the need for catalysis or azeotropic removal of water.