Highly Efficient and Simple Route to Synthesize N-(4-Acetylphenyl)-4-chlorobenzenesulfonamide and Its Crystal Structure

doi:10.1134/S1063774517070136

Paper

Highly Efficient and Simple Route to Synthesize N-(4-Acetylphenyl)-4-chlorobenzenesulfonamide and Its Crystal Structure

Published Dec 1, 2017 · T. Kobkeatthawin, S. Chantrapromma, C. S. C. Kumar

Crystallography Reports

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Abstract

The one-pot synthesis of N-(4-acetylphenyl)-4-chlorobenzenesulfonamide under base conditions is carried out. The present method offers several advantages such as excellent yields, short reaction times and high purity. The chemical structure was elucidated using 1H-NMR, FT-IR and UV-Vis spectroscopy. The crystal structure of the substance was determined by single crystal X-ray structure analysis. The molecule is in a V-shape. The two substituted benzene rings make the dihedral angle of 84.31(9)°. In the crystal packing, the molecules are linked by N–H···O and C–H···O hydrogen bonds into double chains along the b-axis. The crystal is further stabilized by weak C−H···O, C−Cl···π and π···π interactions.

Study Snapshot

This one-pot method efficiently synthesizes N-(4-acetylphenyl)-4-chlorobenzenesulfonamide with high purity and excellent yields, offering potential for industrial applications.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Highly Efficient and Simple Route to Synthesize N-(4-Acetylphenyl)-4-chlorobenzenesulfonamide and Its Crystal Structure

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References

Design and synthesis of some novel 4-Chloro-N-(4-(1-(2-(2-cyanoacetyl)hydrazono)ethyl)phenyl) benzenesulfonamide derivatives as anticancer and radiosensitizing agents.

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Effect of humic monomers on the adsorption of sulfamethoxazole sulfonamide antibiotic into a high silica zeolite Y: An interdisciplinary study.

Humic monomers, vanillin and caffeic acid, influence the adsorption of sulfamethoxazole into high silica zeolite Y, with vanillin showing reversible adsorption and caffeic acid being irreversible.

Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives.

Novel chromone-based sulfonamide derivatives show promising cytotoxic activity against MCF-7 and A-549 cancer cell lines, with enhanced proapoptotic activity in both tumor types.

Synthesis and Biological Investigation of some Novel Sulfonamide and Amide Derivatives Containing Coumarin Moieties

Novel sulfonamide and amide derivatives containing coumarin moieties show good antioxidant properties, but no significant antimicrobial activity.

N-(4-Acetylphenyl)-4-methoxybenzenesulfonamide

N-(4-Acetylphenyl)-4-methoxybenzenesulfonamide has a V-shaped conformation and strong C-H interactions, with a dihedral angle of 86.56 (9)° and a V-shaped conformation.

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