Paper
Highly Efficient Synthesis of Novel Fluorine Bearing Quinoline-4-carboxylic Acid and the Related Compounds as Amylolytic Agents
Published Mar 15, 2012 · M. Makki, D. Bakhotmah, R. M. Abdel-Rahman
Informs Journal on Computing
Q1 SJR score
19
Citations
1
Influential Citations
Abstract
Highly efficient syntheses of novel fluorine bearing quinoline-4-carboxylic acids and the related compounds had been achieved from cyclocondensation of 2-amino-5-fluorophenyl glyoxylic acid 1 with benzoyle asetanilides 2 in boiling DMF, to give the target 3. Decarboxylation of 3 produced 6-fluoro-2-phenyl-3-(substituted amino)-keto-quinolines 4, while that reaction underwent refluxing, afforded 7-fluoro-1-(aryl)-3-phenyl-pyrrolo[3,4-c] quinoline-2,9-diones 5. Structure of the products has been established from their elemental and spectral analysis. All targets exhibited a high to moderate activity against some Aspergillus fungi as amylolytic agents.
Study Snapshot
Novel fluorine-bearing quinoline-4-carboxylic acids show high to moderate activity against Aspergillus fungi as amylolytic agents.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Full text analysis coming soon...
References
Quinolone analogs 11: Synthesis of novel 4‐quinolone‐3‐carbohydrazide derivatives with antimalarial activity
Novel 4-quinolone-3-carbohydrazide derivatives show promising antimalarial activity based on in vitro screening data.
2012·15citations·Y. Kurasawa et al.·Journal of Heterocyclic Chemistry
Journal of Heterocyclic Chemistry
Synthesis of N-substituted 2-[(1E)-alkenyl]-4-(1H)-quinolone derivatives as antimycobacterial agents against non-tubercular mycobacteria
N-substituted 2-[(1E)-alkenyl]-4-(1H)-quinolone derivatives show potent antimycobacterial activity against non-tubercular mycobacteria, with lipophilicity increasing antimycobacterial activity.
2011·18citations·A. Wube et al.·European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry
Novel heterocyclic derivatives of pyrano[3,2-c]quinolinone from 3-(1-ethy1-4-hydroxy-2-oxo-2(1H)-quinolin-3-yl)-3-oxopropanoic acid
This study synthesized novel heterocyclic derivatives of pyrano[3,2-c]quinolinone from 3-(1-ethyl-4-hydroxy-2-oxo-2(1H)-quinolin-3-yl)-3-oxopropanoic acid, which show promising
2010·14citations·M. Ibrahim et al.·European Journal of Chemistry
European Journal of Chemistry
Whole-cell biocatalysis: Evaluation of new hydrophobic ionic liquids for efficient asymmetric reduction of prochiral ketones
New hydrophobic ionic liquids with [PF6]- and [NTF]-anions show the best results in biphasic asymmetric reductions of prochiral ketones in whole-cell biocatalysis.
2009·106citations·Stefan Bräutigam et al.·Enzyme and Microbial Technology
Enzyme and Microbial Technology
Fluorine in medicinal chemistry: a century of progress and a 60-year retrospective of selected highlights.
Fluorine has significantly contributed to medicinal innovations and diagnostics over the past 60 years, advancing various medical fields and playing a key role in future medical advances.
2009·303citations·R. Filler et al.·Future medicinal chemistry
Future medicinal chemistry
Citations
QSAR studies of quinoline alkaloids camptothecin derivatives for prediction anticancer activity using linear and nonlinear methods
The BP-ANN model is superior to GA-MLR for predicting anticancer activity of CPT derivatives, providing a more accurate estimate for their pIC50 values.
2024·1citation·Shahaboddin Mohebbi et al.·International Journal of Quantum Chemistry
International Journal of Quantum Chemistry
6-Amino-2-(4-fluorophenyl)-4-(trifluoromethyl)quinoline: Insight into the Crystal Structure, Hirshfeld Surface Analysis and Computational Study
6-amino-2-(4-fluorophenyl)-4-(trifluoromethyl)quinoline (1) shows potential as a drug candidate due to its lipophilicity, size, polarity, insolubility, and flexibility, and its potential inhibitory effects on various enzymes.
2022·16citations·M. G. Babashkina et al.·Polycyclic Aromatic Compounds
Polycyclic Aromatic Compounds
Ultrasound Synthesis of Benzimidazolo-1,3,5-Triazine Derivatives and Their Anti-Histamine and Anti-Diabetic Activities
Ultrasound synthesis of benzimidazolo-1,3,5-triazine derivatives reveals promising anti-diabetic and anti-histamine properties, with compounds 3c and 3e showing the best inhibition results.
2019·3citations·Suhailah S. Al-jameel et al.·Oriental Journal Of Chemistry
Oriental Journal Of Chemistry
Recent advances in catalytic asymmetric intermolecular oxidation of alkynes.
Gold-catalyzed intermolecular oxidation of alkynes offers a safer and more efficient alternative to hazardous diazocarbonyl compounds for carbene generation, with potential for asymmetric synthesis processes.
2019·8citations·W. Shen et al.·Organic & biomolecular chemistry
Organic & biomolecular chemistry
Synthesis, Characterization, and Antileishmanial Activity of Certain Quinoline-4-carboxylic Acids
Q1 (2-methylquinoline-4-carboxylic acid) shows the most active antileishmanial activity among the synthesized compounds, offering potential as a new antileishmanial drug candidate.
2019·16citations·Mazin A. S. Abdelwahid et al.·Journal of Chemistry
Journal of Chemistry
An Efficient One-Pot Three-Component Synthesis of Some New Polyhydroquinolines via Enaminone Intermediates
This study presents a safe, simple, and fast method for synthesis of new polyhydroquinoline derivatives, potentially useful for pharmaceutical drugs.
2017·6citations·A. A. Abdelhamid et al.·Journal of Heterocyclic Chemistry
Journal of Heterocyclic Chemistry
Synthesis and biological evaluation of fluorine substituted pyrazolo[4,3-e][1,2,4]triazines as purine analogues
Fluorine substituted pyrazolo[4,3-e][1,2,4]triazines show potential as purine analogues, with enzymatic assays indicating their enzymatic activity.
2017·12citations·Reda M. Abdel-Rahman et al.·Journal of Saudi Chemical Society
Journal of Saudi Chemical Society
Convenient one-step synthesis of pyrrolo[3,4-c]quinolin-1-ones via TMSCl-catalyzed cascade reactions of isatins and β-enamino ketones
This one-step method for synthesis of pyrrolo[3,4-c]quinoline-1-ones using TMSCl-catalyzed cascade reactions of isatins and -enamino ketones provides efficient and facile production of this compound under mild conditions.
2016·14citations·Hui Xu et al.·RSC Advances
RSC Advances