Highly selective gem-difluoroallylation of organoborons with bromodifluoromethylated alkenes catalyzed by palladium.

doi:10.1021/ja4114825

Paper

DOI: 10.1021/ja4114825

Highly selective gem-difluoroallylation of organoborons with bromodifluoromethylated alkenes catalyzed by palladium.

Published Jan 14, 2014 · Qiao‐Qiao Min, Z. Yin, Zhange Feng

Journal of the American Chemical Society

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140

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Abstract

A first example of Pd-catalyzed gem-difluoroallylation of organoborons using 3-bromo-3,3-difluoropropene (BDFP) in high efficiency with high α/γ-substitution regioselectivity has been developed. The reaction can also be extended to substituted BDFPs and has advantages of low catalyst loading (0.8 to 0.01 mol %), broad substrate scope, and excellent functional group compatibility, thus providing a facile route for practical application in drug discovery and development.

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Study Snapshot

This study developed a highly selective, efficient, and low-catalyzed gem-difluoroallylation of organoborons using 3-bromo-3,3-difluoropropene (BDFP), offering a facile route for drug discovery and development.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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