A highly efficient and regioselective halogenation reaction of unsymmetrical pyridine N-oxide under mild conditions is described. The methodology provides a practical access to various 2-halo-substituted pyridines, which are pharmaceutically important intermediates.

This study presents a highly efficient and regioselective halogenation reaction of unsymmetrical pyridine N-oxide, providing practical access to various 2-halo-substituted pyridines, which are pharmaceutically important intermediates.

Paper

Highly Regioselective Halogenation of Pyridine N-Oxide: Practical Access to 2-Halo-Substituted Pyridines.

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