In the presence of 1,1,2-trichloroethane, a novel procedure for the Pd-C catalytic N-debenzylation of benzylamines was established. The method proceeded in a synergistic catalytic system and directly gave the products as crystal amine hydrochlorides in practically quantitative yields.

This novel Pd-C catalytic method efficiently N-debenzylates benzylamines in a synergistic catalytic system, yielding crystal amine hydrochlorides in quantitative yields.

Paper

Highly chemoselective Pd-C catalytic hydrodechlorination leading to the highly efficient N-debenzylation of benzylamines.

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