Highly selective synthesis of 1-phenylpentane-1, 4-diones, and (E)-5-hydroxy-5-phenylpent-3-en-2-ones catalyzed by organophosphorus compounds

doi:10.1002/HC.20568

Paper

Highly selective synthesis of 1-phenylpentane-1, 4-diones, and (E)-5-hydroxy-5-phenylpent-3-en-2-ones catalyzed by organophosphorus compounds

Published Jan 12, 2010 · Qing Zhang, Yan Qiao, Min Huang

Heteroatom Chemistry

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Abstract

1-Phenylpentane-1, 4-diones, and (E)-5-hydroxy-5-phenylpent-3-en-2-ones were synthesized via organophosphine-catalyzed addition reaction of but-3-en-2-one with aldehydes. The features of the present protocols include high selectivity, operational simplicity, atom economy, and mild reaction conditions without transition metals. © 2010 Wiley Periodicals, Inc. Heteroatom Chem 20:425–430, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/hc.20568

Study Snapshot

Organophosphorus compounds catalyze the selective synthesis of 1-phenylpentane-1, 4-diones and (E)-5-hydroxy-5-phenylpent-3-en-2-ones, offering operational simplicity, atom economy, and mild reaction conditions without transition metals.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Highly selective synthesis of 1-phenylpentane-1, 4-diones, and (E)-5-hydroxy-5-phenylpent-3-en-2-ones catalyzed by organophosphorus compounds

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References

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Diastereoselective synthesis of γ-hydroxy α,β-epoxyesters and their conversion into β-hydroxy α-sulfenyl γ-butyrolactones

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Citations

Phosphine Organocatalysis.

Nucleophilic phosphine catalysis reactions are categorized by electrophilic components, with sections on alkenes, allenes, alkynes, and MBH alcohol derivatives, and sections on non-carbon-carbon multiple bond-containing starting materials.