The first preparation of iodoaziridines is described. The addition of diiodomethyllithium to N-Boc-imines affords these novel aziridines in high yields. The reaction proceeds in one-pot via a highly diastereoselective cyclisation of an amino gem-diiodide intermediate.

This study presents a novel one-pot synthesis of iodoaziridines using diiodomethyllithium and N-Boc-imines, enabling the rapid and efficient preparation of novel aziridines.

Paper

Highly cis-selective synthesis of iodo-aziridines using diiodomethyllithium and in situ generated N-Boc-imines.

References

Citations