Paper
Histomorphologic changes induced by methyl isocyanate in lungs of rats and rabbits
Published May 1, 1987 · S. Pant, R. Srivastava, R. Vijayaraghavan
Bulletin of Environmental Contamination and Toxicology
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Abstract
Methyl isocyanate is a highly reactive compound and its biological effects are due to its reactivity as acylating agent. It causes corrosive damage to tissue exposed by inhalation and topical application. The available literature contains information on the gross morphological changes induced by MIC on the lungs. Discolored lungs with tissue necrosis and mottled red to reddening of entire lung surface have been reported following exposure to MIC. However, the effects of varying concentrations of MIC on the lung architecture has apparently not been studied in detail. This could delineate the possible mechanism of damage caused to lungs. The present study was undertaken with this aim in view.
Methyl isocyanate exposure can cause severe morphological changes in the lungs of rats and rabbits, with varying concentrations causing different effects on lung architecture.
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