Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase.

doi:10.1016/j.bmcl.2015.10.006

Paper

Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase.

Published Nov 15, 2015 · Fan-Wei Peng, Ting-Ting Wu, Zi-Wei Ren

Bioorganic & medicinal chemistry letters

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32

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Abstract

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In Vitro Study

Study Snapshot

Compound 6l, derived from 4-anilinoquinazoline and hydroxamic acid, shows the most potent inhibitory activities against VEGFR-2 and HDAC, with potential antiproliferative activity against MCF-7 breast cancer cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase.

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