Paper
Hydroxyurea (therapeutics and mechanism): metabolism, carbamoyl nitroso, nitroxyl, radicals, cell signaling and clinical applications.
Published 2011 · P. Kovacic
Medical hypotheses
Q2 SJR score
54
Citations
2
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Hydroxyurea shows potential as a practical medicine for treating cancer, sickle cell disease, HIV, skin, and genes, with its metabolism, mechanism, and toxicity being key players in its biological effects.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Hydroxamic acids (therapeutics and mechanism): chemistry, acyl nitroso, nitroxyl, reactive oxygen species, and cell signaling
Hydroxamic acids show potential as anticancer agents, with suberoylanilide hydroxamic acid showing promise in clinical trials, but their toxicity remains to be addressed.
2011·19citations·P. Kovacic et al.·Journal of Receptors and Signal Transduction
Journal of Receptors and Signal Transduction
Hydroxyurea stimulates the release of ATP from rabbit erythrocytes through an increase in calcium and nitric oxide production.
Hydroxyurea stimulates ATP release from rabbit red blood cells by increasing calcium and nitric oxide production, improving blood flow and reducing vaso-occlusive crises.
2010·14citations·Madushi Raththagala et al.·European journal of pharmacology
European journal of pharmacology
How safe is bisphenol A? Fundamentals of toxicity: metabolism, electron transfer and oxidative stress.
Human exposure to bisphenol A (BPA) is not negligible, with potential toxic effects on liver, DNA, genes, CNS, reproductive system, and kidney, and a connection to reactive oxygen species and oxidative stress.
2010·87citations·P. Kovacic·Medical hypotheses
Medical hypotheses
Simplifying the complexity of cell signaling in medicine and the life sciences: radicals and electrochemistry.
Cell signaling can be simplified by focusing on electrochemistry and radical species, complementing the new mechanics approach and incorporating anions and cations.
2010·13citations·P. Kovacic·Medical hypotheses
Medical hypotheses
Integrated approach to the mechanisms of thyroid toxins: electron transfer, reactive oxygen species, oxidative stress, cell signaling, receptors, and antioxidants
Thyroid toxicity involves electron transfer, reactive oxygen species, oxidative stress, cell signaling, receptors, and antioxidants, with antioxidants showing beneficial effects in countering toxicity.
2010·29citations·P. Kovacic et al.·Journal of Receptors and Signal Transduction
Journal of Receptors and Signal Transduction
Citations
Initial Low-Dose Hydroxyurea and Anagrelide Combination in Essential Thrombocythemia: Comparable Response with Lower Toxicity
Low-dose combination of hydroxyurea and anagrelide shows feasible clinical outcomes with significantly lower severe adverse events compared to conventional monotherapy in essential thrombocythemia patients.
2024·0citations·Young Hoon Park et al.·Journal of Clinical Medicine
Journal of Clinical Medicine
Resumption of Spermatogenesis and Fertility Post Withdrawal of Hydroxyurea Treatment
Hydroxyurea-induced hypogonadism in male mice can be reversed after a 4-month withdrawal, making it a potential candidate for male contraception.
2023·2citations·C. Virgous et al.·International Journal of Molecular Sciences
International Journal of Molecular Sciences
Mathematical Modeling of Hydroxyurea Therapy in Individuals with Sickle Cell Disease
Our mathematical models can help optimize hydroxyurea dosing regimens and study the impact of non-adherence on sickle cell disease patients.
2022·1citation·A. Pandey et al.·Pharmaceutics
Pharmaceutics
Biochemical Evaluation of the Effects of Hydroxyurea in Vitro on Red Blood Cells
A concentration of 0.8 mM hydroxyurea is more efficient in protecting against free radicals and treating diseases like sickle cell anemia, preferentially stimulating the pentose pathway over the glycolytic pathway.
2021·6citations·C. O. Renó et al.·Antioxidants
Antioxidants
Hydroxyurea affects in vitro porcine oocyte maturation through increased apoptosis and oxidative stress
Exposure to 20 M hydroxyurea during porcine oocyte maturation leads to significant oxidative stress and apoptosis, affecting their developmental ability.
2021·6citations·Wei Gao et al.·Bioscience Reports
Bioscience Reports
Hydroxyurea regulates the development and survival of B16 Melanoma Cells by upregulating MiR-7013-3p
Hydroxyurea treatment alters miRNA expression in B16 melanoma cells, promoting apoptosis and inhibiting melanin production, proliferation, and migration.
2021·3citations·Yi-Jie Huang et al.·International Journal of Medical Sciences
International Journal of Medical Sciences
Hydroxyurea treatment of sickle cell disease: towards a personalized model-based approach
A personalized model-based approach using mathematical modeling can optimize hydroxyurea treatment for sickle cell disease by addressing interpatient variability, dose optimization, and non-adherence.
2021·6citations·A. Pandey et al.·Journal of Translational Genetics and Genomics
Journal of Translational Genetics and Genomics
Sickle Cell Anemia: Variants in the CYP2D6, CAT, and SLC14A1 Genes Are Associated With Improved Hydroxyurea Response
Variants in the CYP2D6, CAT, and SLC14A1 genes are strongly associated with improved hydroxyurea response in sickle cell anemia patients, potentially serving as genetic markers.
2020·8citations·S. C. M. A. Yahouédéhou et al.·Frontiers in Pharmacology
Frontiers in Pharmacology
Qualitative Analysis of Hydroxyurea
This study developed qualitative methods for identifying and verifying the purity of hydroxyurea using IR, UV spectroscopy, and TLC, with acetone and ethyl acetate as mobile phases, resulting in less chemical waste and minimizing operator health risks.
2020·4citations·S. Santos et al.