Hypocholesterolaemia in the rat after p-chlorophenoxyisobutyric acid (CPIB) administration as a synthetic triglyceride, 1,3-dipalmitoyl 2(p-chlorophenoxyisobutyroyl)-rac-glycerol.

doi:10.1016/0009-8981(77)90428-4

Paper

Hypocholesterolaemia in the rat after p-chlorophenoxyisobutyric acid (CPIB) administration as a synthetic triglyceride, 1,3-dipalmitoyl 2(p-chlorophenoxyisobutyroyl)-rac-glycerol.

Published Sep 1, 1977 · J. Owen, J. Billimoria

Clinica chimica acta; international journal of clinical chemistry

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4

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Study Snapshot

Synthetic lipids, such as 1,3-dipalmitoyl 2(p-chlorophenoxyisobutyroyl)-rac-glycerol, can effectively lower plasma cholesterol levels in rats, suggesting potential for oral drug delivery.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Hypocholesterolaemia in the rat after p-chlorophenoxyisobutyric acid (CPIB) administration as a synthetic triglyceride, 1,3-dipalmitoyl 2(p-chlorophenoxyisobutyroyl)-rac-glycerol.

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References

Potentiating of lipid-lowering activity of clofibrate by combining with low doses of 3-pyridylcarbinol in rats.

Combining clofibrate with low doses of 3-pyridylcarbinol can improve the lipid-lowering activity of both drugs in rats with hypercholesterolemia.

Plasma Concentrations and Bioavailability of Clofibrate After Administration to Human Subjects

Clofibrate capsules show high bioavailability, allowing for rapid and sustained release of the drug into the bloodstream after 12 hours of administration.

The hypocholesterolemic action of eritadenine in the rat.

Eritadenine, a compound found in Japanese mushrooms, effectively lowers plasma cholesterol levels in rats, with more than 10 times the activity of clofibrate when administered orally.

Fatty acid activation and acyl transfer in rat liver during clofibrate feeding.

Clofibrate feeding in rats increases fatty acid activation and acyl transfer enzyme activity, potentially regulating fatty acid metabolism and influencing serum triglyceride levels.

The additive effects of clofibrate and probucol (DH-581) on rat serum cholesterol.

Clofibrate and probucol combined significantly reduce serum cholesterol levels in male albino rats compared to either drug alone.

Citations

Bioavailability of Phenytoin Following Oral Administration of Phenytoin‐lipid Conjugates to Rats

Phenytoin is well-tolerated by rats when administered orally in lipid conjugates, with a bioavailability of 91.3%.

Studies on intestinal lymphatic absorption of drugs. I. Lymphatic absorption of alkyl ester derivatives and alpha-monoglyceride derivatives of drugs.

Alpha-monoglyceride derivatives of drugs are mainly absorbed via the intestinal lymphatic system and transported into blood, yielding the parent drug in blood.

Effects of clofibrate and tiadenol on the elimination of lipids and bile acids in rat bile

Clofibrate and tiadenol both decrease cholesterol output in bile, with clofibrate having a greater effect at 200 mg/kg/day, and both drugs lower serum lipid levels more effectively in females than males.