Hypoglycemic Activity of 3,5 Dimethylisoxazole

doi:10.3181/00379727-113-28461

Paper

Hypoglycemic Activity of 3,5 Dimethylisoxazole

Published Jul 1, 1963 · W. Dulin, G. Gerritsen

Proceedings of the Society for Experimental Biology and Medicine

UNKNOWN SJR score

19

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0

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Abstract

Summary 3, 5 dimethylisoxazole (U-21221) was found to be 188 times more potent orally than tolbutamide in glucose-primed fasted intact rats. U-21221 also increased glucose oxidation by intact rats. It did not lower blood sugar of eviscerate rats but was active in alloxan diabetic animals which were unresponsive to tolbutamide. It was suggested that the mechanism of action of 3,5 dimethylisoxazole was by stimulation of glucose oxidation by the gut and/or liver.

Non-RCT

Animal Study

Study Snapshot

3,5 dimethylisoxazole (U-21221) is a potent oral hypoglycemic agent, 188 times more potent than tolbutamide, primarily due to stimulation of glucose oxidation by the gut and/or liver.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Hypoglycemic Activity of 3,5 Dimethylisoxazole

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