Paper
Identification of 5,6-dihydroimidazo[2,1-b]thiazoles as a new class of antimicrobial agents.
Published Nov 1, 2016 · Yangmei Li, Nina Bionda, R. Fleeman
Bioorganic & medicinal chemistry
Q2 SJR score
13
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
5,6-dihydroimidazo[2,1-b]thiazoles show potential as a new class of antimicrobial agents against drug-resistant bacteria, with the most active compound showing a 3.7 g/mL MIC value against MRSA and potentially targeting DNA gyrase.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Mechanisms of daptomycin resistance in Staphylococcus aureus: role of the cell membrane and cell wall
Daptomycin resistance in Staphylococcus aureus develops through diverse mechanisms, including mutations in key cell membrane and cell wall genes, and cell wall modifications.
2013·299citations·A. Bayer et al.·Annals of the New York Academy of Sciences
Annals of the New York Academy of Sciences
Adenylate Kinase Release as a High-Throughput-Screening-Compatible Reporter of Bacterial Lysis for Identification of Antibacterial Agents
The AK assay is a sensitive and efficient method for identifying new antimicrobial agents, with potential applications in identifying novel drug development scaffolds.
2012·66citations·Anna C. Jacobs et al.·Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy
Exploiting bacterial DNA gyrase as a drug target: current state and perspectives
New antibacterials targeting DNA gyrase are needed due to bacterial resistance to current drugs, and new inhibitory modes are needed to combat this issue.
2011·486citations·F. Collin et al.·Applied Microbiology and Biotechnology
Applied Microbiology and Biotechnology
Thiazoles: having diverse biological activities
Thiazole derivatives show potential as diverse biological activities, including antioxidants, analgesics, and anti-inflammatory drugs with lesser side effects.
2011·195citations·S. Kashyap et al.·Medicinal Chemistry Research
Medicinal Chemistry Research
Novel dual-targeting benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possessing potent antibacterial activity: intelligent design and evolution through the judicious use of structure-guided design and structure-activity relationships.
The novel benzimidazole urea inhibitors of DNA gyrase and topoisomerase IV possess potent antibacterial activity against a wide spectrum of pathogens, offering a potential solution to antibiotic resistance.
2008·201citations·P. Charifson et al.·Journal of medicinal chemistry
Journal of medicinal chemistry
Invasive methicillin-resistant Staphylococcus aureus infections in the United States.
Invasive MRSA infection is a major public health issue primarily related to healthcare, with high incidence rates in individuals 65 years and older, blacks, and males, and is now found in communities.
2007·3751citations·R. M. Klevens et al.·JAMA
JAMA
Alternatives to vancomycin for the treatment of methicillin-resistant Staphylococcus aureus infections.
Alternative treatments for methicillin-resistant Staphylococcus aureus infections include linezolid, daptomycin, tigecycline, quinupristin/dalfopristin, and novel glycopeptides.
2007·204citations·S. Micek·Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
In Vitro Characterization of the Antibacterial Spectrum of Novel Bacterial Type II Topoisomerase Inhibitors of the Aminobenzimidazole Class
VRT-125853 and VRT-752586 show excellent antibacterial activity against a wide spectrum of pathogens, with low frequencies of spontaneous resistance, and show potential as new antibiotics against bacterial resistance.
2006·68citations·N. Mani et al.·Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy
Citations
Current Development of Thiazole-Containing Compounds as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus.
Thiazole-containing compounds show potential as antibacterial candidates against methicillin-resistant Staphylococcus aureus (MRSA) when modified with appropriate structural modifications.
2024·20citations·Hang Liu et al.·ACS infectious diseases
ACS infectious diseases
Stereoselective Synthesis of a Novel Series of Dispiro-oxindolopyrrolizidines Embodying Thiazolo[3,2-a]benzimidazole Motif: A Molecular Electron Density Theory Study of the Mechanism of the [3 + 2] Cycloaddition Reaction
The study presents a one-pot multi-component reaction for stereoselective synthesis of novel dispiro-oxindolopyrrolizidines incorporating a thiazolo[3,2-a]benzimidazole scaffold, using Molecular Electron Density Theory to explain the
2023·0citations·A. Barakat et al.·Chemistry
Chemistry
From Bench to Bedside: What Do We Know about Imidazothiazole Derivatives So Far?
Imidazothiazole derivatives show promising antitumor, anti-infection, anti-inflammatory, and antioxidant effects, aiding in the development of imidazothiazole-based drugs.
2023·3citations·Mu Guo et al.·Molecules
Molecules
In vitro activity, ultrastructural analysis and in silico pharmacokinetic properties (ADMET) of thiazole compounds against adult worms of Schistosoma mansoni.
PBT2 and PBT5 show promising antiparasitic activity against Schistosoma mansoni adult worms, with 200 M concentrations causing 100% mortality after 3 hours of incubation.
2023·3citations·Débora Verônica Sarmento Pereira da Silva et al.·Acta tropica
Acta tropica
Biological Applications of Imidazothiazole Scaffolds: A Current Review
Imidazothiazole scaffolds have numerous biological applications in medicine, including anticancer, antimalarial, and antiviral treatments, and their design is crucial for future drug design.
2022·3citations·R. Senthil Kumar et al.·Journal of Advanced Chemical Sciences
Journal of Advanced Chemical Sciences