Bromadol can serve as a powerful and versatile agent in medicinal chemistry. In this paper, 2-phenylethanol was first identified as a main impurity in commercial Bromadol sample by HPLC. HPLC quantitative analysis method for impurity 2-phenylethanol in Bromadol has also been established for the first time. By our new HPLC analysis method, the impurity 2-phenylethanol was found to be 9.6% by weight. The identified main impurity 2-phenylethanol can be successfully removed by heating under vacuum, which gave an easy way to purify Bromadol for mass production.

2-phenylethanol is a major impurity in Bromadol, affecting its purity, and can be removed by heating under vacuum for mass production.

Paper

Identification and Quantitative Analysis of 2- Phenylethanol as Major Impurity in Bromadol by HPLC

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