Paper
Imaging the Effects of Methylphenidate on Brain Dopamine: New Model on Its Therapeutic Actions for Attention-Deficit/Hyperactivity Disorder
Published Jun 1, 2005 · N. Volkow, Gene-Jack Wang, J. Fowler
Biological Psychiatry
Q1 SJR score
351
Citations
20
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Rigorous Journal
Highly CitedStudy Snapshot
Methylphenidate hydrochloride improves ADHD symptoms by blocking dopamine transporters and increasing dopamine levels in the brain, potentially improving school performance.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Evidence that methylphenidate enhances the saliency of a mathematical task by increasing dopamine in the human brain.
Methylphenidate increases dopamine in the brain, making academic tasks more interesting and potentially improving attention and performance in ADHD treatment.
2004·269citations·N. Volkow et al.·The American journal of psychiatry
The American journal of psychiatry
The worldwide prevalence of ADHD: is it an American condition?
ADHD prevalence is as high in many non-US children as in US children, challenging the belief that it is primarily an American disorder.
2003·1553citations·S. Faraone et al.·World psychiatry : official journal of the World Psychiatric Association
World psychiatry : official journal of the World Psychiatric Association
Efficacy of a new pattern of delivery of methylphenidate for the treatment of ADHD: effects on activity level in the classroom and on the playground.
Continuous, ascending delivery of methylphenidate effectively reduces activity and inappropriate behavior in children with ADHD, with situational effects depending on the environment.
2002·103citations·J. Swanson et al.·Journal of the American Academy of Child and Adolescent Psychiatry
Journal of the American Academy of Child and Adolescent Psychiatry
Acute Handling Stress Modulates Methylphenidate-induced Catecholamine Overflow in the Medial Prefrontal Cortex
Short exposure to restraint stress can cause persistent alterations in mesocorticolimbic dopamine-ergic activity, as evidenced by altered responses to methylphenidate challenges in the medial prefrontal cortex.
2002·65citations·D. Marsteller et al.·Neuropsychopharmacology
Neuropsychopharmacology
“Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect
Dopamine in the dorsal striatum plays a role in nonhedonic food motivation in humans, with methylphenidate amplifying this effect.
2002·471citations·N. Volkow et al.·Synapse
Synapse
Citations
Intranasal Transfersomal Based In Situ Gel for Augmenting Methylphenidate Bioavailability and Brain Delivery: In Vitro and In Vivo Evaluation
The MPH-TFs Gel, an intranasal transfersomal-based gel, significantly improves methylphenidate bioavailability and brain delivery compared to orally administered solutions.
2024·1citation·Rida Khalil et al.·Journal of Drug Delivery Science and Technology
Journal of Drug Delivery Science and Technology
From neurons to brain networks, pharmacodynamics of stimulant medication for ADHD
Stimulants for ADHD optimize task-related brain networks, increase perceived saliency, and reduce interference from the default mode network, potentially reducing brain alterations observed in untreated individuals.
2024·2citations·V. Parlatini et al.·Neuroscience & Biobehavioral Reviews
Neuroscience & Biobehavioral Reviews
Pharmacogenomics and Personalized Medicine
CYP2D6 and CYP2C19 polymorphisms were not involved in tamoxifen efficacy, but may be useful in predicting tamoxifen efficacy and clinical outcomes in post-menopausal breast cancer patients receiving adjuvant tamoxi
2024·209citations·Steven H. Y. Wong·International Journal of Pharmaceutical Research and Applications
International Journal of Pharmaceutical Research and Applications
Reduced dopamine transporter availability in drug‐naive adult attention‐deficit/hyperactivity disorder
Drug-naive adult ADHD patients show reduced dopamine transporter availability in the nucleus accumbens, which is linked to inattentiveness and involvement of the cortico-striato-thalamo-cortical circuit.
2024·1citation·Shuntaro Itagaki et al.·PCN Reports: Psychiatry and Clinical Neurosciences
PCN Reports: Psychiatry and Clinical Neurosciences
Methylphenidate Ameliorates Behavioural and Neurobiological Deficits in Executive Function for Patients with Chronic Traumatic Brain Injury
Methylphenidate treatment improves executive function and neurobiological connectivity in chronic traumatic brain injury patients, potentially benefiting their cognitive performance.
2024·2citations·Alexander R. D. Peattie et al.·Journal of Clinical Medicine
Journal of Clinical Medicine
Methylphenidate alleviates cognitive dysfunction caused by early manganese exposure: Role of catecholaminergic receptors
Methylphenidate effectively alleviates lasting attentional and sensorimotor dysfunction caused by developmental manganese exposure, with the mechanism of action involving catecholaminergic receptors.
2024·0citations·S. Beaudin et al.·Progress in Neuro-Psychopharmacology and Biological Psychiatry
Progress in Neuro-Psychopharmacology and Biological Psychiatry