Improved synthesis of 1,3-propanediol derivatives having a diethoxyphosphoryldifluoroethyl functional group at the 2-position: Application to chemoenzymatic synthesis of novel acyclic nucleotide analogues of adenosine bisphosphates

doi:10.1055/S-2004-834941

Paper

Improved synthesis of 1,3-propanediol derivatives having a diethoxyphosphoryldifluoroethyl functional group at the 2-position: Application to chemoenzymatic synthesis of novel acyclic nucleotide analogues of adenosine bisphosphates

Published Feb 1, 2005 · T. Murano, H. Kobayakawa, Y. Yuasa

Synthesis

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Abstract

An alternative synthesis of 1,3-propanediol 1 having a diethoxyphosphoryldifluoroethyl group was examined. The method readily provided a multi-gram quantity of 1. The propanediol 1 was chemo-enzymatically transformed to acyclic nucleotide analogues for adenosine bisphosphates.

Study Snapshot

This study developed a novel method for synthesising 1,3-propanediol 1 with a diethoxyphosphoryldifluoroethyl group, which can be used to chemo-enzymatically transform it into novel acyclic nucleotide analogue

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Improved synthesis of 1,3-propanediol derivatives having a diethoxyphosphoryldifluoroethyl functional group at the 2-position: Application to chemoenzymatic synthesis of novel acyclic nucleotide analogues of adenosine bisphosphates

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References

Hydrolases in Organic Synthesis: Regio- and Stereoselective Biotransformations

Hydrolases enable regio- and stereoselective biotransformations in organic synthesis, offering improved enantioselective reactions and diverse applications in various reaction media.

Citations

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