Improved synthesis of 2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol

Paper

Improved synthesis of 2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol

Published 2009 · S. Hongbin

Journal of China Pharmaceutical University

Q4 SJR score

0

Citations

0

Influential Citations

Semantic Scholar

Abstract

Aim:To improve the synthesis for 2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol.Methods:Dehydration of D-mannitol,followed by a reaction sequence of selective protection,benzylation,deprotection,tritylation,benzylation and removal of the trityl group,afforded the title compound.Results:Based on the improvement of the reported synthetic route,2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol was synthesized in seven steps from D-mannitol with a total yield of 8.3%.Conclusion:This new method features mild reaction conditions and facile work-up.

Study Snapshot

This study improved the synthesis of 2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol from D-mannitol, resulting in a yield of 8.3% and mild reaction conditions.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Improved synthesis of 2,5-anhydro-3,4,6-tri-O-benzyl-D-glucitol

Sign up to use Study Snapshot

References

Citations