Paper
Improved Synthesis of 1-[2-Amino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol
Published 2009 ยท Tao Yong
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Abstract
The preparative method of 1-[2-amino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol,which is the intermediate of venlafaxine,was improved by using potassium borohydride and aluminum chloride as reducing agents under mild conditions and at low costs.The overall yield was 78.2%.
Study Snapshot
The improved method using potassium borohydride and aluminum chloride effectively synthesizes 1-[2-amino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol, an intermediate in venlafaxine, with a 78.2% overall yield.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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