Inactivation of rat liver cytochrome P450 (P450) by N,N-dimethylformamide and N,N-dimethylacetamide.

doi:10.1016/S0378-4274(01)00384-8

Paper

DOI: 10.1016/S0378-4274(01)00384-8

Inactivation of rat liver cytochrome P450 (P450) by N,N-dimethylformamide and N,N-dimethylacetamide.

Published Oct 15, 2001 · R. Tolando, A. Zanovello, R. Ferrara

Toxicology letters

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Abstract

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In Vitro Study

Study Snapshot

Both N,N-dimethylformamide and N,N-dimethylacetamide inactivate rat liver cytochrome P450, potentially causing hepatotoxicity, and both compounds cause dose-dependent loss of enzyme and microsomal haem.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Separate Determination by Gas‐Chromatography of Dimethylformamide, Dimethylacetamide, Monomethylformamide and Monomethylacetamide in Urine for Biological Monitoring

This study developed a gaschromatographic method for simultaneous determination of dimethylformamide (DMF) and dimethylacetamide (DMA), as well as their metabolites, in urine samples from workers exposed to these compounds.

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Citations

DOI: 10.1016/j.fct.2023.114198

Allyl methyl disulfide (AMDS) prevents N,N-dimethyl formamide-induced liver damage by suppressing oxidative stress and NLRP3 inflammasome activation.

AMDS effectively reduces liver damage caused by N,N-dimethylformamide (DMF) by suppressing oxidative stress and inactivating the NF-B pathway and NLRP3 inflammasome.

2023·5citations·Longteng Li et al.·Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

DOI: 10.1016/j.ecoenv.2020.111166

Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity.

DMF exposure leads to liver damage through deregulated proteins, lipids, and metabolites, affecting multiple signaling and metabolic pathways.

2020·28citations·Lin Xu et al.·Ecotoxicology and environmental safety

Ecotoxicology and environmental safety

DOI: 10.1093/qjmed/hcz282

Dimethylacetamide-induced toxic hepatitis in spandex workers: Clinical presentation & treatment outcomes.

Chinese drugs effectively rescue functional loss in dimethylacetamide-induced toxic hepatitis, promoting long-term health and preventing functional loss in spandex workers.

2020·10citations·Jinglei Wang et al.·QJM : monthly journal of the Association of Physicians

QJM : monthly journal of the Association of Physicians

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Enhancement of Flame Retardancy of Colorless and Transparent Semi-Alicyclic Polyimide Film from Hydrogenated-BPDA and 4,4′-oxydianiline via the Incorporation of Phosphazene Oligomer

Incorporating phosphazene oligomer into semi-alicyclic polyimide films significantly enhances their flame retardancy, with a UL 94 VTM-0 classification and improved thermal stability.

2020·13citations·Xiao Wu et al.·Polymers

Polymers

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The essential role of CYP2E1 in metabolism and hepatotoxicity of N,N-dimethylformamide using a novel Cyp2e1 knockout mouse model and a population study

CYP2E1 plays a crucial role in the metabolism and hepatotoxicity of N,N-dimethylformamide, with a variant allele linked to higher blood levels in DMF-exposed workers.

2019·10citations·Zhijun Wu et al.·Archives of Toxicology

Archives of Toxicology