An environmentally benign and efficient process for the preparation of 3-(substituted methylthio)-4-phenyl-5- (3,4,5-trimethoxyphenyl)-4H-1,2,4-triazole was achieved by the reaction of 4-phenyl-5-(3,4,5-trimethoxyphenyl)- 4H-1,2,4-triazole-3-thiol with different halides in aqueous media mediated by indium trichloride in high yields.

Indium trichloride-mediated facile synthesis of 3-(substituted methylthio)-4-phenyl-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazole in water provides an environmentally friendly and efficient method for preparing this compound.

Paper

Indium Trichloride-Mediated Facile Synthesis of 3-(Substituted methylthio)-4-phenyl-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazole in Water†

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