Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors.

doi:10.1016/J.BMC.2005.07.073

Paper

Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors.

Published Dec 15, 2005 · A. Kalgutkar, B. Crews, S. Saleh

Bioorganic & medicinal chemistry

Q2 SJR score

85

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1

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Abstract

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In Vitro Study

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Study Snapshot

Reverse ester/amide derivatives of indomethacin show potential as selective COX-2 inhibitors, broadening the scope of this strategy for other NSAIDs.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Indolyl esters and amides related to indomethacin are selective COX-2 inhibitors.

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