Paper

Induction of cytochromes P450 2B and 2E1 in rat liver by isomeric picoline N-oxides.

Published Dec 1, 1997 · M. Murray, R. Sefton, R. Martini

Toxicology letters

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Abstract

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Non-RCTAnimal Study

Study Snapshot

Isomeric picoline N-oxides rapidly induce CYP2B or CYP2E1 in rat liver, potentially contributing to pyridine hepatotoxicity by enhancing microsomal lipid peroxidation.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Induction of cytochromes P450 2B and 2E1 in rat liver by isomeric picoline N-oxides.

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