Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): part II.

doi:10.1016/j.bmc.2008.09.027

Paper

Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): part II.

Published Nov 15, 2007 · Jean-Baptiste Véron, H. Allouchi, C. Enguehard-Gueiffier

Bioorganic & medicinal chemistry

Q2 SJR score

94

Citations

1

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Highly Cited

Study Snapshot

Imidazo[1,2-a]pyridines with a 5 membered heterocycle in the 6 or 8 position show the most potent antiviral activity against human cytomegalovirus and varicella-zoster virus, independent of viral thymidine kinase.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Paper

Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): part II.

Sign up to use Study Snapshot

References

Antiviral drugs for cytomegalovirus diseases.

Cytomegalovirus drugs have made significant advances in disease management, but are limited by intolerable toxicities, oral bioavailability, and drug resistance.

A general and efficient method for the copper-catalyzed cross-coupling of amides and thiophenols with 6-halogenoimidazo[1,2-a]pyridines

Copper-catalyzed cross-coupling of amides and thiophenols with 6-halogenoimidazo[1,2-a]pyridines efficiently prepares novel 6-amido and 6-phenylsulfanylimidazo[1,2-a]pyridine derivatives with low cost

Design of translactam HCMV protease inhibitors as potent antivirals

Translactam HCMV protease inhibitors show potential as potent and selective antivirals, with good pharmacokinetics, brain and ocular penetration in animals.

Antiviral drugs in current clinical use.

37 licensed antiviral drugs are currently in clinical use for treating various viral infections, including HIV, hepatitis B, and cytomegalovirus.

Clinical and biologic aspects of human cytomegalovirus resistance to antiviral drugs.

Human cytomegalovirus drug resistance is a life-threatening condition in immunocompromised individuals, with resistance emerging in transplantation due to mutations in key viral genes.

Comparative study on the reactivity of 6-haloimidazo[1,2-a]pyridine derivatives towards Negishi- and Stille-coupling reactions

Negishi-cross-coupling conditions are inefficient for 6-haloimidazo[1,2-a]pyridine derivatives, while Stille-cross-coupling conditions are efficient for various commercially available halogenated heterocycles.

Ipso- or cine-substitutions of 6-haloimidazo[1,2-a]pyridine derivatives with different azoles depending on the reaction conditions.

6-haloimidazo[1,2-a]pyridine derivatives show high reactivity towards different azoles, with ipso substitution using copper catalyst and cine substitution in the absence of copper.

Citations