Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV).

doi:10.1016/j.bmc.2007.03.061

Paper

Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV).

Published 2007 · Jean-Baptiste Véron, C. Enguehard-Gueiffier, R. Snoeck

Bioorganic & medicinal chemistry

Q2 SJR score

10

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0

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Abstract

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In Vitro Study

Study Snapshot

The 6-halogeno and 6-phenylimidazo[1,2-a]pyridine derivatives 4c-d and 5b show the most potent antiviral activity against human cytomegalovirus and varicella-zoster virus, with a mechanism of action independent of viral thymidine

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV).

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