Influence of methylation process on the degree of quaternization of N-trimethyl chitosan chloride.

doi:10.1016/S0939-6411(03)00151-6

Paper

Influence of methylation process on the degree of quaternization of N-trimethyl chitosan chloride.

Published 2004 · A. Polnok, G. Borchard, J. Verhoef

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

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118

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5

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Abstract

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Study Snapshot

The degree of quaternization of N-trimethyl chitosan chloride (TMC) is higher with sodium hydroxide as the base and increases with the number of reaction steps, affecting its solubility and drug transport properties across mucosal membranes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Influence of methylation process on the degree of quaternization of N-trimethyl chitosan chloride.

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References

The relationship between the absolute molecular weight and the degree of quaternisation of N-trimethyl chitosan chloride

The degree of quaternization of N-trimethyl chitosan chloride (TMC) affects its solubility, absorption enhancing ability, and mucoadhesive properties, with decreasing molecular weight correlated to increased intrinsic viscosity.

Intestinal Absorption of Octreotide Using Trimethyl Chitosan Chloride: Studies in Pigs

Trimethyl chitosan chloride (TMC) at pH 7.4 significantly enhances the intestinal absorption of octreotide in pigs, with a more potent effect than chitosan HCl at pH 5.5.

A review of chitin and chitosan applications

Chitin and chitosan show high potential as functional materials in various fields, with recent progress in chitin chemistry highlighting its potential as an underutilized resource.

Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement.

Chitosan enhances drug absorption in mucus-free intestinal epithelial cells, but its modest absorption-enhancing effects in rat ileum may be due to the mucus barrier.

Effect of the degree of quaternization of N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2).

The degree of quaternization of N-trimethyl chitosan chloride (TMC) affects its permeability and potential use as an absorption enhancer across intestinal epithelia.

Citations