Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2',4,4',5,5'-hexachlorobiphenyl.

doi:10.1093/TOXSCI/35.1.1

Paper

Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2',4,4',5,5'-hexachlorobiphenyl.

Published Jan 1, 1997 · Feng Zhao, K. Mayura, Nathan Kocurek

Fundamental and applied toxicology : official journal of the Society of Toxicology

24

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Abstract

3,3',4,4',5-Pentachlorobiphenyl (pentaCB) caused a dose-dependent induction of chicken embryolethality, malformations, edema, and liver lesions at doses ranging from 0.5 to 12.0 microg/kg. In contrast, no embryotoxicity was observed after treatment with 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB. In eggs cotreated with 2.0 microg/kg, 3,3',4,4',5-pentaCB plus 10, 25, or 50 mg/kg 2,2',4,4',5,5'-hexaCB, there was significant protection from 3,3',4,4',5-pentaCB-induced embryo malformations, edema, and liver lesions, whereas no inhibition of embryolethality was observed. These results further extend the response-specific nonadditive interactions of binary mixtures of polychlorinated biphenyls (PCBs) and should be considered in the development of approaches for hazard assessment of PCB mixtures and related compounds.

Non-RCTAnimal Study

Study Snapshot

2,2',4,4',5,5'-hexachlorobiphenyl effectively protects chicken embryos from 3,3',4,4',5-pentachlorobiphenyl-induced malformations, edema, and liver lesions, but not embryolethality.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Inhibition of 3,3',4,4',5-pentachlorobiphenyl-induced chicken embryotoxicity by 2,2',4,4',5,5'-hexachlorobiphenyl.

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