Paper
Inhibition of bacterial cell division protein FtsZ by cinnamaldehyde.
Published Sep 15, 2007 · Prerna N. Domadia, S. Swarup, A. Bhunia
Biochemical pharmacology
Q1 SJR score
233
Citations
15
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro Study
Highly CitedStudy Snapshot
Cinnamaldehyde, a natural compound from spices, inhibits bacterial cell division by binding to FtsZ, disrupting Z-ring formation, and inhibiting its assembly dynamics, making it a potential lead compound for anti-FtsZ drug design.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Inhibitory effect of cinnamaldehyde, derived from Cinnamomi cortex, on the growth of influenza A/PR/8 virus in vitro and in vivo.
Cinnamaldehyde, derived from Cinnamomi cortex, effectively inhibits influenza A/PR/8 virus growth in vitro and in vivo, potentially supporting its use in Kampo medicines for acute respiratory infectious diseases.
2007·136citations·Katsumi Hayashi et al.·Antiviral research
Antiviral research
Cinnamaldehyde induces endothelium-dependent and -independent vasorelaxant action on isolated rat aorta.
Cinnamaldehyde induces both endothelium-dependent and -independent vasorelaxation in isolated rat aorta, with nitric oxide playing a role in endothelium-dependent relaxation and calcium channel blockage in endothelium-
2006·90citations·Ayano Yanaga et al.·Biological & pharmaceutical bulletin
Biological & pharmaceutical bulletin
The prokaryotic cytoskeleton: a putative target for inhibitors and antibiotics?
Inhibiting the bacterial cytoskeleton could lead to novel therapeutic agents against pathogenic bacteria, such as dichamanetin, SRI-3072, and sanguinarine.
2006·126citations·W. Vollmer·Applied Microbiology and Biotechnology
Applied Microbiology and Biotechnology
A 4‐Aminofurazan Derivative—A189—Inhibits Assembly of Bacterial Cell Division Protein FtsZ In Vitro and In Vivo
A189, a 4aminofurazan derivative, inhibits FtsZ GTPase activity, leading to bacterial cell death by perturbing FtsZ ring formation and making bacterial cells filamentous.
2006·36citations·Hideaki Ito et al.·Microbiology and Immunology
Microbiology and Immunology
Microencapsulation of Cinnamon Oleoresin by Spray Drying Using Different Wall Materials
A 4:1:1 blend of gum arabic:maltodextrin:modified starch effectively protects cinnamon oleoresin from degradation, offering better protection than gum arabic alone.
2006·90citations·S. Vaidya et al.·Drying Technology
Drying Technology
Citations
Lysozyme/Tracheal Antimicrobial Peptide-Based Tissue-Specific Expression Antimicrobial Plasmids Show Broad-Spectrum Antibacterial Activities in the Treatment of Mastitis in Mice.
Lysozyme/tracheal antimicrobial peptide-based TSEAP effectively reduce clinical symptoms of mastitis in mice, offering a potential non-antibiotic treatment for bacterial diseases.
2024·0citations·Yi Yang et al.·Advanced biology
Advanced biology
Recent advances in studies on FtsZ inhibitors.
FtsZ inhibitors show promise as a promising target for developing new antimicrobial drugs against multidrug-resistant bacteria.
2024·1citation·Yan-Ting Wang et al.·Biochemical pharmacology
Biochemical pharmacology
Staphylococcus aureus major cell division protein FtsZ assembly is inhibited by silibinin, a natural flavonolignan that also blocked bacterial growth and biofilm formation.
Silibinin, a natural flavonolignan, effectively inhibits Staphylococcus aureus growth and biofilm formation by targeting the cell division protein FtsZ.
2024·0citations·Prithvi Basak et al.·International journal of biological macromolecules
International journal of biological macromolecules
Trans-Cinnamaldehyde Inhibition of Pyruvate Dehydrogenase: Effects on Streptococcus mutans Carbohydrate Metabolism.
Trans-cinnamaldehyde inhibits Streptococcus mutans growth and biofilm formation by disrupting its carbohydrate metabolism and targeting pyruvate dehydrogenase, a potential target for developing new antibacterial drugs.
2024·0citations·Hanyi Zhang et al.·Journal of proteome research
Journal of proteome research
The study of honokiol as a natural product-based antimicrobial agent and its potential interaction with FtsZ protein
Honokiol shows potent antibacterial activity against multidrug-resistant bacteria, including MRSA and VRE, and when combined with -lactam antibiotics, shows strong synergistic effects against drug-resistant S. aureus strains.
2024·0citations·Ning Sun et al.·Frontiers in Microbiology
Frontiers in Microbiology
Study on Oleum cinnamomi Inhibiting Cutibacterium acnes and Its Covalent Inhibition Mechanism
Oleum cinnamomi inhibits Cutibacterium acnes by covalent binding to target proteins, hindering amino acid transport and disrupting energy metabolism, offering potential new control strategies for gram-positive anaerobic bacteria.
2024·1citation·Huayong Peng et al.·Molecules
Molecules