Specific irreversible inhibition of human and boar N-acetyl-β-D-hexosaminidase by 2-acetamido-2-deoxy-β-D-glucopyranosyl isothiocyanate

doi:10.1016/0006-291X(77)90325-4

Paper

Specific irreversible inhibition of human and boar N-acetyl-β-D-hexosaminidase by 2-acetamido-2-deoxy-β-D-glucopyranosyl isothiocyanate

Published Jan 24, 1977 · M. L. Shul'man, O. E. Lakhtina, A. Khorlin

Biochemical and Biophysical Research Communications

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Abstract

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Study Snapshot

2-acetamido-2-deoxy--D-glucopyranosyl isothiocyanate (I) irreversibly inhibits human and boar N-acetyl--D-hexosaminidase, with dialysis not restoring enzyme activity.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Specific irreversible inhibition of human and boar N-acetyl-β-D-hexosaminidase by 2-acetamido-2-deoxy-β-D-glucopyranosyl isothiocyanate

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References

Citations

Synthesis and conformational analysis of 1,2-cis fused bicyclic α-d-galactofuranosyl thiocarbamate from per-O-tert-butyldimethylsilyl-β-d-galactofuranosyl isothiocyanate.

The 1,2-cis fused bicyclic -d-galactofuranosyl thiocarbamate synthesized from per-O-tert-butyldimethylsilyl--d-galactofuranosyl isothiocyanate shows two stable twist

Glycosyl azide—a novel substrate for enzymatic transglycosylations

Glycosyl azides are efficient donors for glycosidases, facilitating transglycosylations with comparable or better yields than common O-glycosides.

SYNTHESIS AND ANTIVIRAL EVALUATION OF SOME NEW GLYCOSYLTHIOUREAS CONTAINING A QUINAZOLINONE NUCLEUS

New glycosylthioureas containing a quinazolinone nucleus show promising antiviral activity, with potential for further development and commercialization.

A practical one-pot synthesis of O-unprotected glycosyl thioureas

This study developed a one-pot method for preparing various O-unprotected glycosyl thioureas from -d-glycopyranosylamines and O-unprotected glycopyranosyl isothiocyanates.

Synthesis of 6,7-dideoxy-7-isothiocyanatoheptoses: stable fully unprotected monosaccharide isothiocyanates.

Stable fully unprotected monosaccharide isothiocyanates, 6,7-dideoxy-7-isothiocyanatoheptoses, have been synthesized and show promising stability in aqueous solution without base formation.

The Thiocarbonyl Group in Carbohydrate Chemistry

Thiocarbonyl carbohydrate derivatives show potential in synthetic, biological, and technical applications due to their interactions between functional groups and their diverse applications.

The reaction of p-Tolyl isoselenocyanate with primary and secondary amines: A multinuclear magnetic resonance study

P-tolyl isoselenocyanate reacts with primary and secondary amines to produce selenoureas, which can be used for nucleic acid sequencing and have high sensitivity to chemical and electronic environments.

Synthesis and application of 13C enriched phenylisothiocyanate as a 13C NMR protein probe.

Phenylisothiocyanate enriched with 13C can effectively label and study proteins using 13C NMR, enabling functionalization of amino groups and distinct amino group distinctions.

Simple and efficient synthesis of O-unprotected glycosyl thiourea and isourea derivatives from glycosylamines

This study presents a one-pot method for synthesis of O-unprotected glycosyl thiourea and isourea derivatives from glycosylamines, enabling the preparation of d-gluco trehazolin analogues.