Paper
Inhibition of human carboxylesterases by magnolol: Kinetic analyses and mechanism.
Published Aug 1, 2019 · Yunqing Song, Zi-miao Weng, Tongyi Dou
Chemico-biological interactions
Q1 SJR score
24
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Magnolol, a constituent of Magnolia officinalis, strongly inhibits human carboxylesterases 1, while its inhibition of hCE2 is substrate-dependent, aiding in understanding metabolic interactions between the two compounds.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Inhibition of UGT1A1 by natural and synthetic flavonoids.
Natural and synthetic flavonoids show varying inhibitory effects on UGT1A1, with C-3 and C-7 hydroxyl groups enhancing inhibition, and flavonoid glycosides showing weaker effects.
2019·32citations·Xin-Yu Liu et al.·International journal of biological macromolecules
International journal of biological macromolecules
Sensing carboxylesterase 1 in living systems by a practical and isoform-specific fluorescent probe
A practical and isoform-specific fluorescent probe has been developed for real-time monitoring of carboxylesterase 1 in biological systems, offering potential for drug discovery, clinical practice, and fundamental research.
2019·31citations·Le-le Ding et al.·Chinese Chemical Letters
Chinese Chemical Letters
Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1.
Nevadensin, a natural flavonoid from Lysionotus pauciflorus Maxim, shows the best combination of inhibition potency and selectivity against human carboxylesterase 1, offering potential for novel hCE1 inhibitor development.
2018·48citations·Ya-Qiao Wang et al.·International journal of biological macromolecules
International journal of biological macromolecules
Evidence for Shikonin acting as an active inhibitor of human carboxylesterases 2: Implications for herb–drug combination
Shikonin, a natural herb from Lithospermum erythrorhizon, effectively inhibits human carboxylesterases 2, potentially affecting drug metabolism and pharmacokinetics.
2018·6citations·Jia-Nan Li et al.·Phytotherapy Research
Phytotherapy Research
Characterization and structure-activity relationship studies of flavonoids as inhibitors against human carboxylesterase 2.
5,6-dihydroxyflavone is the most potent inhibitor of human carboxylesterase 2, aiding in the development of more potent and selective flavonoid-type hCE2 inhibitors.
2018·53citations·Zi-miao Weng et al.·Bioorganic chemistry
Bioorganic chemistry
Citations
Novel Ratiometric Surface-Enhanced Raman Scattering (SERS) Biosensor for Ultrasensitive Quantitative Monitoring of Human Carboxylesterase-1 in Hepatocellular Carcinoma Cells Using Ag-Au Nanoflowers as SERS Substrate.
Ratiometric SERS biosensors using Ag-Au nanoflowers enable ultrasensitive and interference-free detection of human carboxylesterase-1 in HepG-2 cells, offering a novel approach for ultrasensitive and interference-free monitoring of intracellular hCE1.
2024·16citations·Hao Cheng et al.·Analytical chemistry
Analytical chemistry
Pig Liver Cytosolic Carboxylesterase 1 and Its Inhibition by Remdesivir and Sofosbuvir
Remdesivir and sofosbuvir are potent inhibitors of pig liver cytosolic carboxylesterase 1, which metabolizes xenobiotics and can be used to treat pig diseases.
2024·0citations·Shesterenko Yevgeniia et al.·ChemistrySelect
ChemistrySelect
Inhibitory effects of phthalate esters (PAEs) and phthalate monoesters towards human carboxylesterases (CESs).
Phthalate esters significantly inhibit the activity of human carboxylesterases, potentially disrupting endogenous substance metabolism.
2023·3citations·Jia-min Gong et al.·Toxicology and applied pharmacology
Toxicology and applied pharmacology
Potential herb–drug interactions between anti-COVID-19 drugs and traditional Chinese medicine
Potential herb-drug interactions exist between anti-COVID-19 drugs and traditional Chinese medicine, potentially affecting efficacy and safety in patients.
2023·25citations·Ling Ye et al.·Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica. B
Magnolol Loaded on Carboxymethyl Chitosan Particles Improved the Antimicrobial Resistance and Storability of Kiwifruits
Magnolol@CMCS particles effectively improve kiwifruit's antimicrobial resistance, delay hardness and nutritional changes, and enhance storability.
2023·4citations·Feixu Mo et al.·Foods
Foods
Discovery and Characterization of the Naturally Occurring Inhibitors Against Human Pancreatic Lipase in Ampelopsis grossedentata
Ampelopsis grossedentata extract contains strong inhibitors against human pancreatic lipase, supporting its anti-obesity and lipid-lowering effects.
2022·12citations·Xiaodong Qin et al.·Frontiers in Nutrition
Frontiers in Nutrition
Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19
9,10-dihydrophenanthrene derivatives show potential as orally administered SARS-CoV-2 3CLpro inhibitors, with C1 showing the most potent activity and metabolic stability in the gastrointestinal tract.
2021·25citations·Jian-wei Zhang et al.·European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry
Carboxylesterase inhibitors from clinically available medicines and their impact on drug metabolism.
Clinically available hCES inhibitors from medications may trigger drug/herb-drug interactions, highlighting the need for further research on CES-mediated interactions.
2021·18citations·Yunqing Song et al.·Chemico-biological interactions
Chemico-biological interactions