Paper

The inhibition of catechol O-methyltransferase and monoamine oxidase by tetralone and indanone derivatives substituted with the nitrocatechol moiety.

Published Jun 28, 2021 · Andries D de Beer, L. Legoabe, A. Petzer

Bioorganic chemistry

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Abstract

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In Vitro Study

Study Snapshot

Nitrocatechol compounds, such as 4-chromanone and 1-tetralone, show potential for peripheral COMT inhibition, which is crucial for treating Parkinson's disease.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

The inhibition of catechol O-methyltransferase and monoamine oxidase by tetralone and indanone derivatives substituted with the nitrocatechol moiety.

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