Inhibition of COX-1 activity and COX-2 expression by 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its semi-synthetic derivatives.

doi:10.1016/j.bmcl.2011.07.040

Paper

DOI: 10.1016/j.bmcl.2011.07.040

Inhibition of COX-1 activity and COX-2 expression by 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its semi-synthetic derivatives.

Published Oct 1, 2011 · S. Genovese, M. Curini, P. Gresele

Bioorganic & medicinal chemistry letters

Q2 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

3-(4′-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its semi-synthetic analogues effectively inhibit COX-2 expression and activity in monocytes, potentially offering anti-inflammatory properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1016/j.jnutbio.2010.07.004

Effects of resveratrol and other wine polyphenols on vascular function: an update.

Moderate wine drinking reduces cardiovascular morbidity and mortality due to the presence of resveratrol and other wine polyphenols, which protect against ischemic cardiovascular events by reducing oxidative stress, promoting nitric oxide production, and modulating adhesive molecules.

2011·176citations·P. Gresele et al.·The Journal of nutritional biochemistry

The Journal of nutritional biochemistry

DOI: 10.1016/j.lfs.2010.02.008

A natural propenoic acid derivative activates peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta).

4′-geranyloxyferulic acid activates PPAR/ and inhibits cell proliferation in a human skin cancer cell line, suggesting its potential biological effects.

2010·14citations·S. Genovese et al.·Life sciences

Life sciences

DOI: 10.1021/jm900735p

Design, synthesis, and examination of neuron protective properties of alkenylated and amidated dehydro-silybin derivatives.

Alkenylated dehydro-silybin analogues show better neuroprotective properties than acetamidated derivatives, potentially benefiting therapeutic potential in neurodegenerative disorders.

2009·44citations·Leixiang Yang et al.·Journal of medicinal chemistry

Journal of medicinal chemistry

DOI: 10.2310/JIM.0b013e31819aaa76

The Anti-Inflammatory Effects of Prostaglandins

Prostaglandins, long considered proinflammatory, also have anti-inflammatory effects, contributing to both inflammation initiation and resolution, potentially regulating tissue inflammation and vascular diseases.

2009·224citations·J. Scher et al.·Journal of Investigative Medicine

Journal of Investigative Medicine

DOI: 10.1016/J.BMCL.2007.07.058

Synthesis and anti-inflammatory activity of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid and its ester derivatives.

The paracetamol, guaiacol, and hydroquinone esters of 3-(4'-geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid (1) show higher anti-inflammatory activity than the parent compound, similar to indomethacin.

2007·8citations·F. Epifano et al.·Bioorganic & medicinal chemistry letters

Bioorganic & medicinal chemistry letters

Citations

DOI: 10.1021/acsomega.3c00692

Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective

This paper explores the chemical structures and inhibitory activity of various COX-II inhibitors, aiming to develop next-generation inhibitors with improved potency and reduced side effects.

2023·9citations·Sandhya Chahal et al.·ACS Omega

ACS Omega

DOI: 10.1016/j.phytochem.2023.113706

Novel insights into the biomolecular mechanism of action of 4'-geranyloxyferulic acid, a colon cancer chemopreventive agent.

4'-geranyloxyferulic acid, a colon cancer chemopreventive agent, causes apoptosis in cultured Caco-2 cells by causing a time- and dose-dependent decrease in cell viability and generating reactive oxygen species.

2023·0citations·Lucia Palumbo et al.·Phytochemistry

Phytochemistry

DOI: 10.3390/antiox12020259

Protection of Mitochondrial Potential and Activity by Oxyprenylated Phenylpropanoids

Oxyprenylated phenylpropanoids, such as auraptene 1 and 7-isopentenyloxycoumarin 2, effectively protect mitochondrial potential and activity, with their protective effects comparable to resveratrol.

2023·4citations·F. Epifano et al.·Antioxidants

Antioxidants

DOI: 10.1016/j.ejmech.2017.08.038

Recent acquisitions on oxyprenylated secondary metabolites as anti-inflammatory agents.

Oxyprenylated secondary metabolites from plants, fungi, and bacteria show potential as novel anti-inflammatory agents, with diverse mechanisms of action and structure-activity relationships.

2017·22citations·S. Fiorito et al.·European journal of medicinal chemistry

European journal of medicinal chemistry

DOI: 10.1515/jcim-2015-0106

Biochemical fingerprint and pharmacological applications of Barleria noctiflora L.f. leaves

Barlerinoside, a compound found in Barleria noctiflora L.f. leaves, exhibits strong antioxidant and antihistamine properties, with potential applications in treating various diseases.

2016·8citations·Sangilimuthu Alagar Yadav et al.·Journal of Complementary and Integrative Medicine

Journal of Complementary and Integrative Medicine