Paper

Inhibition of debrisoquin clearance in perfused rat livers and inhibition of dextromethorphan metabolism in human liver microsomes by 4-hydroxydebrisoquin or other metabolites of debrisoquin.

Published May 1, 1992 · S. Jaruratanasirikul, Allen D. Cooper, Terrence F. Blaschke

Drug metabolism and disposition: the biological fate of chemicals

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Abstract

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In Vitro Study

Study Snapshot

4-hydroxydebrisoquin and other metabolites of debrisoquin inhibit CYP2D1 and CYP2D6 enzymes, suggesting different pathways for dextromethorphan metabolism in humans and rats.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Inhibition of debrisoquin clearance in perfused rat livers and inhibition of dextromethorphan metabolism in human liver microsomes by 4-hydroxydebrisoquin or other metabolites of debrisoquin.

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