Paper

Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action.

Published Nov 15, 1998 · DOI · H. Ginsburg, O. Famin, Jianmin Zhang

Biochemical pharmacology

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro StudyHighly Cited

Study Snapshot

Chloroquine and amodiaquine effectively kill malaria parasites by inhibiting heme degradation by glutathione, allowing heme to accumulate in membranes and disrupting ion homeostasis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action.

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