Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity

doi:10.1038/onc.2012.493

Paper

Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity

Published Oct 1, 2013 · Alexander Arlt, S. Sebens, S. Krebs

Oncogene

Q1 SJR score

300

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10

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Abstract

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In Vitro Study

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Study Snapshot

Trigonelline, an efficient Nrf2 inhibitor, enhances pancreatic cancer cell sensitivity to anticancer drugs and TRAIL-induced apoptosis, potentially improving anticancer therapy.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity

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