Inhibition of nucleoside phosphorylase cleavage of 5-fluoro-2'-deoxyuridine by 2,4-pyrimidinedione derivatives.

doi:10.1016/0006-2952(80)90170-7

Paper

Inhibition of nucleoside phosphorylase cleavage of 5-fluoro-2'-deoxyuridine by 2,4-pyrimidinedione derivatives.

Published Apr 1, 1980 · P. W. Woodman, A. Sarrif, C. Heidelberger

Biochemical pharmacology

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30

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Abstract

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In Vitro Study

Study Snapshot

Pyrimidinedione derivatives with smaller, non-hydrophobic groups at C-5 or C-6 can effectively inhibit the cleavage of 5-fluoro-2'-deoxyuridine in mammalian cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Inhibition of nucleoside phosphorylase cleavage of 5-fluoro-2'-deoxyuridine by 2,4-pyrimidinedione derivatives.

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