[Inhibition of cyclic nucleotide phosphodiesterase from rabbit heart by hydroxypyridines].

Paper

[Inhibition of cyclic nucleotide phosphodiesterase from rabbit heart by hydroxypyridines].

Published 1983 · N. B. Polyansky, L. D. Smirnov, A. Shvedova

Voprosy meditsinskoi khimii

UNKNOWN SJR score

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Abstract

3-Hydroxypyridines, which are inhibitors of cyclic nucleotide phosphodiesterase, affected reversibly and non-competitively the enzyme molecule as compared with cAMP. A number of substances was found exhibiting high inhibitory and antioxidant activities, high inhibitory and low antioxidant activities, as well as low inhibitory and high antioxidant activities. Elucidation of the 3-hydroxypyridines action via antioxidant or phosphodiesterase pathways became possible.

Study Snapshot

3-Hydroxypyridines inhibit cyclic nucleotide phosphodiesterase in rabbit hearts, with some showing both inhibitory and antioxidant properties, allowing for elucidation of their action via antioxidant or phosphodiesterase pathways.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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[Inhibition of cyclic nucleotide phosphodiesterase from rabbit heart by hydroxypyridines].

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